Drug interactions
Human papillomavirus vaccine + Ponesimod
Severity: Moderate
Human papillomavirus vaccine and Ponesimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod reduces circulating lymphocytes and may blunt the antibody response to inactivated vaccines such as HPV vaccine. Protection may therefore be incomplete.
What this interaction means in plain words
Human papillomavirus vaccine and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Ponesimod belongs to Central Nervous System.
Why it happens
Sphingosine-1-phosphate receptor modulation sequesters lymphocytes in lymphoid tissue, impairing vaccine immune response.
What to do
Complete vaccination at least 4 weeks before starting ponesimod where possible. If vaccinating during therapy, consider the likelihood of a reduced response and review immunity afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Human papillomavirus vaccine with Ponesimod?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponesimod reduces circulating lymphocytes and may blunt the antibody response to inactivated vaccines such as HPV vaccine. Protection may therefore be incomplete.
How serious is the interaction between Human papillomavirus vaccine and Ponesimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 4 weeks before starting ponesimod where possible. If vaccinating during therapy, consider the likelihood of a reduced response and review immunity afterward.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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