Drug interactions
Hydralazine + Lisdexamfetamine
Severity: Moderate
Hydralazine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase blood pressure and heart rate and can reduce the antihypertensive effect of hydralazine. Tachycardia may also be intensified.
What this interaction means in plain words
Hydralazine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Sympathomimetic release of norepinephrine opposes the vasodilator effect of hydralazine.
What to do
Check blood pressure and heart rate regularly after starting or changing the stimulant dose. Intensify antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Hydralazine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Hydralazine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase blood pressure and heart rate and can reduce the antihypertensive effect of hydralazine. Tachycardia may also be intensified.
How serious is the interaction between Hydralazine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and heart rate regularly after starting or changing the stimulant dose. Intensify antihypertensive therapy if control is lost.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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