Drug interactions
Hydrochlorothiazide + Hydrochlorothiazide-losartan
Severity: Moderate
Hydrochlorothiazide and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding it separately duplicates the same drug. This leads to excess thiazide exposure with risks of volume depletion, electrolyte disturbance, hyperuricemia and hyperglycemia.
What this interaction means in plain words
Hydrochlorothiazide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leading to excess thiazide effect on renal sodium and potassium handling.
What to do
Avoid duplicate hydrochlorothiazide and adjust the regimen to a single source. Monitor electrolytes and renal function if the duplication was present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding it separately duplicates the same drug. This leads to excess thiazide exposure with risks of volume depletion, electrolyte disturbance, hyperuricemia and hyperglycemia.
How serious is the interaction between Hydrochlorothiazide and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate hydrochlorothiazide and adjust the regimen to a single source. Monitor electrolytes and renal function if the duplication was present.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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