Drug interactions
Hydrochlorothiazide + Ipratropium-salbutamol
Severity: Moderate
Hydrochlorothiazide and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide causes renal potassium loss, and salbutamol shifts potassium into cells. Combined use can cause clinically relevant hypokalemia, especially with high-dose or nebulized salbutamol. This raises arrhythmia risk in susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia via renal potassium wasting and beta-2 mediated intracellular potassium shift.
What to do
Monitor serum potassium, particularly when salbutamol is used heavily, and supplement potassium if necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide causes renal potassium loss, and salbutamol shifts potassium into cells. Combined use can cause clinically relevant hypokalemia, especially with high-dose or nebulized salbutamol. This raises arrhythmia risk in susceptible patients.
How serious is the interaction between Hydrochlorothiazide and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly when salbutamol is used heavily, and supplement potassium if necessary.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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