Drug interactions
Hydrochlorothiazide + Linagliptin-metformin
Severity: Moderate
Hydrochlorothiazide and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and so weaken the glucose-lowering effect of metformin. They may also reduce renal function through volume depletion, which could increase metformin exposure.
What this interaction means in plain words
Hydrochlorothiazide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
Thiazide-induced impaired glucose tolerance (through potassium loss and insulin resistance) opposes metformin; competition for renal tubular secretion may also raise metformin levels.
What to do
Monitor blood glucose and renal function when starting or changing the thiazide, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and so weaken the glucose-lowering effect of metformin. They may also reduce renal function through volume depletion, which could increase metformin exposure.
How serious is the interaction between Hydrochlorothiazide and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or changing the thiazide, and adjust antidiabetic therapy as needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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