Drug interactions
Hydrochlorothiazide + Magnesium
Severity: Moderate
Hydrochlorothiazide and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss and can cause hypomagnesemia with chronic use. This may contribute to hypokalemia and arrhythmia risk.
What this interaction means in plain words
Hydrochlorothiazide and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Thiazide action in the distal tubule reduces magnesium reabsorption.
What to do
Check serum magnesium and potassium periodically in long-term users. Replace magnesium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Magnesium?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide increases urinary magnesium loss and can cause hypomagnesemia with chronic use. This may contribute to hypokalemia and arrhythmia risk.
How serious is the interaction between Hydrochlorothiazide and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium and potassium periodically in long-term users. Replace magnesium if low.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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