Drug interactions
Hydrochlorothiazide + Memantine-donepezil
Severity: Minor
Hydrochlorothiazide and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce renal elimination of memantine through competition at tubular secretion, possibly increasing memantine levels. Clinically relevant effects such as dizziness or confusion are uncommon.
What this interaction means in plain words
Hydrochlorothiazide and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Competition for renal tubular secretion of cationic drugs may reduce memantine clearance.
What to do
No dose change is needed; monitor for dizziness, confusion or sedation in older or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Memantine-donepezil?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may reduce renal elimination of memantine through competition at tubular secretion, possibly increasing memantine levels. Clinically relevant effects such as dizziness or confusion are uncommon.
How serious is the interaction between Hydrochlorothiazide and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for dizziness, confusion or sedation in older or renally impaired patients.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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