Drug interactions
Hydrochlorothiazide + Mesalamine
Severity: Minor
Hydrochlorothiazide and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and the acetylated mesalamine metabolite are both organic anions handled by renal tubular secretion, so competition might slightly raise mesalamine exposure. Thiazide-induced volume depletion could also add to renal risk in patients prone to mesalamine nephrotoxicity.
What this interaction means in plain words
Hydrochlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Possible competition for renal tubular anion secretion.
What to do
No dose adjustment is generally needed; monitor renal function periodically during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Mesalamine?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and the acetylated mesalamine metabolite are both organic anions handled by renal tubular secretion, so competition might slightly raise mesalamine exposure. Thiazide-induced volume depletion could also add to renal risk in patients prone to mesalamine nephrotoxicity.
How serious is the interaction between Hydrochlorothiazide and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor renal function periodically during long-term combined use.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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