Drug interactions
Hydrochlorothiazide + Methoxsalen
Severity: Moderate
Hydrochlorothiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of severe phototoxic reactions such as burns and blistering.
What this interaction means in plain words
Hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of two agents that sensitize skin to ultraviolet light.
What to do
Review the need for the thiazide before phototherapy and adjust UVA dosing cautiously. Counsel strict sun protection and examine the skin for early phototoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Hydrochlorothiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of severe phototoxic reactions such as burns and blistering.
How serious is the interaction between Hydrochlorothiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for the thiazide before phototherapy and adjust UVA dosing cautiously. Counsel strict sun protection and examine the skin for early phototoxicity.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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