Drug interactions
Hydrochlorothiazide + Nadolol
Severity: Minor
Hydrochlorothiazide and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol may slightly raise potassium while hydrochlorothiazide lowers it, so the net potassium effect is small. Both lower blood pressure, and nadolol accumulates in renal impairment or volume depletion.
What this interaction means in plain words
Hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Beta-blockade modestly reduces cellular potassium uptake, offsetting thiazide-induced potassium loss, with additive antihypertensive effects.
What to do
Monitor blood pressure, heart rate and serum potassium periodically, and check renal function in patients at risk of nadolol accumulation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Hydrochlorothiazide with Nadolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol may slightly raise potassium while hydrochlorothiazide lowers it, so the net potassium effect is small. Both lower blood pressure, and nadolol accumulates in renal impairment or volume depletion.
How serious is the interaction between Hydrochlorothiazide and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium periodically, and check renal function in patients at risk of nadolol accumulation.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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