Drug interactions
Hydrochlorothiazide + Nebivolol
Severity: Minor
Hydrochlorothiazide and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol may slightly raise potassium while hydrochlorothiazide lowers it, so the net effect on potassium is small. The combination is used for hypertension and mainly adds to blood pressure lowering.
What this interaction means in plain words
Hydrochlorothiazide and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Beta-blockade modestly impairs cellular potassium uptake, partly offsetting thiazide-induced potassium loss, with additive antihypertensive effects.
What to do
Monitor blood pressure and serum potassium periodically after starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Hydrochlorothiazide with Nebivolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nebivolol may slightly raise potassium while hydrochlorothiazide lowers it, so the net effect on potassium is small. The combination is used for hypertension and mainly adds to blood pressure lowering.
How serious is the interaction between Hydrochlorothiazide and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium periodically after starting or adjusting either drug.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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