Drug interactions
Hydrochlorothiazide + Oliceridine
Severity: Moderate
Hydrochlorothiazide and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and cause hypotension, potentially reducing diuretic efficacy or causing additive blood pressure lowering. Effects are generally modest and manageable in the acute setting.
What this interaction means in plain words
Hydrochlorothiazide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced ADH release and vasodilation/histamine effects pharmacodynamically alter diuretic response and blood pressure.
What to do
Monitor fluid status, urine output and blood pressure, and adjust the diuretic dose if diuresis is diminished or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Hydrochlorothiazide with Oliceridine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids can stimulate antidiuretic hormone release and cause hypotension, potentially reducing diuretic efficacy or causing additive blood pressure lowering. Effects are generally modest and manageable in the acute setting.
How serious is the interaction between Hydrochlorothiazide and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status, urine output and blood pressure, and adjust the diuretic dose if diuresis is diminished or hypotension occurs.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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