Drug interactions
Hydrochlorothiazide + Oxaprozin
Severity: Moderate
Hydrochlorothiazide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive and diuretic effect of thiazides. The combination can also increase the risk of acute kidney injury in volume-depleted or elderly patients.
What this interaction means in plain words
Hydrochlorothiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reduced renal perfusion that opposes thiazide effects.
What to do
Monitor blood pressure, fluid status, electrolytes and renal function. Adjust the antihypertensive regimen if control is lost and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Oxaprozin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive and diuretic effect of thiazides. The combination can also increase the risk of acute kidney injury in volume-depleted or elderly patients.
How serious is the interaction between Hydrochlorothiazide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, electrolytes and renal function. Adjust the antihypertensive regimen if control is lost and ensure adequate hydration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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