Drug interactions
Hydrochlorothiazide + Pivmecillinam
Severity: Minor
Hydrochlorothiazide and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both may use renal tubular secretory pathways, but no clinically significant change in exposure to either drug is established. Practical impact is likely negligible.
What this interaction means in plain words
Hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Theoretical competition for renal tubular secretion of the active mecillinam.
What to do
No specific action required beyond routine monitoring of clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Hydrochlorothiazide with Pivmecillinam?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both may use renal tubular secretory pathways, but no clinically significant change in exposure to either drug is established. Practical impact is likely negligible.
How serious is the interaction between Hydrochlorothiazide and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action required beyond routine monitoring of clinical response.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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