Drug interactions
Hydrochlorothiazide + Probenecid
Severity: Moderate
Hydrochlorothiazide and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide raises serum uric acid and competes for tubular secretion, which can blunt probenecid's uricosuric effect. Gout control may deteriorate.
What this interaction means in plain words
Hydrochlorothiazide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazides compete for renal organic anion secretion and cause volume depletion that increases urate reabsorption, opposing probenecid.
What to do
Monitor serum uric acid and flare frequency. Adjust the probenecid dose or use a non-thiazide antihypertensive if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide raises serum uric acid and competes for tubular secretion, which can blunt probenecid's uricosuric effect. Gout control may deteriorate.
How serious is the interaction between Hydrochlorothiazide and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and flare frequency. Adjust the probenecid dose or use a non-thiazide antihypertensive if control is lost.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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