Drug interactions
Hydrochlorothiazide + Repaglinide
Severity: Minor
Hydrochlorothiazide and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the effect of repaglinide. Glycemic control may worsen, especially with higher thiazide doses.
What this interaction means in plain words
Hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Thiazides impair glucose tolerance via hypokalemia and reduced insulin secretion, opposing the antihyperglycemic effect (pharmacodynamic antagonism).
What to do
Monitor blood glucose when starting or changing the thiazide and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Hydrochlorothiazide with Repaglinide?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may reduce the effect of repaglinide. Glycemic control may worsen, especially with higher thiazide doses.
How serious is the interaction between Hydrochlorothiazide and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the thiazide and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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