Drug interactions
Hydrochlorothiazide + Saxagliptin-metformin
Severity: Moderate
Hydrochlorothiazide and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of antidiabetic therapy. It may also slightly increase metformin levels and volume depletion can impair renal function.
What this interaction means in plain words
Hydrochlorothiazide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Thiazides induce hypokalemia and insulin resistance, and may compete with metformin for renal tubular secretion.
What to do
Monitor blood glucose, potassium and renal function, and adjust antidiabetic doses if control worsens; use the lowest effective thiazide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of antidiabetic therapy. It may also slightly increase metformin levels and volume depletion can impair renal function.
How serious is the interaction between Hydrochlorothiazide and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function, and adjust antidiabetic doses if control worsens; use the lowest effective thiazide dose.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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