Drug interactions
Hydrochlorothiazide + Sulindac
Severity: Moderate
Hydrochlorothiazide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive and diuretic effects of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury. Sulindac may have less renal prostaglandin effect than other NSAIDs but the interaction is still possible.
What this interaction means in plain words
Hydrochlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduces renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, renal function and electrolytes, and keep patients well hydrated. Adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Sulindac?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive and diuretic effects of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury. Sulindac may have less renal prostaglandin effect than other NSAIDs but the interaction is still possible.
How serious is the interaction between Hydrochlorothiazide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and keep patients well hydrated. Adjust the antihypertensive regimen if control is lost.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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