Drug interactions
Hydrochlorothiazide + Treprostinil
Severity: Minor
Hydrochlorothiazide and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and when given with a diuretic such as hydrochlorothiazide the blood pressure lowering effect may be increased. Symptomatic hypotension or dizziness may occur, especially after initiation or dose increases.
What this interaction means in plain words
Hydrochlorothiazide and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from vasodilation by treprostinil and volume depletion or vasodilation from the thiazide.
What to do
Monitor blood pressure and volume status when starting or titrating treprostinil in patients on a thiazide. Reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Treprostinil
Frequently asked questions
Can I take Hydrochlorothiazide with Treprostinil?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a potent vasodilator, and when given with a diuretic such as hydrochlorothiazide the blood pressure lowering effect may be increased. Symptomatic hypotension or dizziness may occur, especially after initiation or dose increases.
How serious is the interaction between Hydrochlorothiazide and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or titrating treprostinil in patients on a thiazide. Reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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