Drug interactions
Hydrochlorothiazide + Umeclidinium-vilanterol
Severity: Moderate
Hydrochlorothiazide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide promotes potassium excretion, and vilanterol can add to the fall in serum potassium. This can lead to hypokalemia and ECG changes, especially at higher beta-agonist exposure.
What this interaction means in plain words
Hydrochlorothiazide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide renal potassium loss and beta2-agonist-induced intracellular potassium shift.
What to do
Monitor serum potassium periodically and replace it when low. Pay particular attention in patients with cardiac disease or other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide promotes potassium excretion, and vilanterol can add to the fall in serum potassium. This can lead to hypokalemia and ECG changes, especially at higher beta-agonist exposure.
How serious is the interaction between Hydrochlorothiazide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace it when low. Pay particular attention in patients with cardiac disease or other QT risk factors.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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