Drug interactions
Hydrochlorothiazide-irbesartan + Indomethacin
Severity: Moderate
Hydrochlorothiazide-irbesartan and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the antihypertensive effect of both the thiazide and the ARB. With these agents together it can also provoke acute kidney injury, particularly in elderly or volume-depleted patients, and may cause hyperkalemia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition causes sodium and water retention and lowers renal perfusion, which is exacerbated by diuretic and ARB effects.
What to do
Avoid prolonged NSAID use where possible; if necessary, ensure adequate hydration and monitor blood pressure, creatinine and potassium early after starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Indomethacin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the antihypertensive effect of both the thiazide and the ARB. With these agents together it can also provoke acute kidney injury, particularly in elderly or volume-depleted patients, and may cause hyperkalemia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged NSAID use where possible; if necessary, ensure adequate hydration and monitor blood pressure, creatinine and potassium early after starting.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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