Drug interactions
Hydrochlorothiazide-irbesartan + Irbesartan
Severity: Moderate
Hydrochlorothiazide-irbesartan and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains irbesartan, so adding separate irbesartan duplicates the ARB. This increases the risk of hypotension, hyperkalemia, and renal dysfunction without added benefit.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leading to excessive angiotensin II receptor blockade.
What to do
Avoid concurrent separate irbesartan. Adjust dose by changing the combination product strength and monitor blood pressure, potassium and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Irbesartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains irbesartan, so adding separate irbesartan duplicates the ARB. This increases the risk of hypotension, hyperkalemia, and renal dysfunction without added benefit.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent separate irbesartan. Adjust dose by changing the combination product strength and monitor blood pressure, potassium and creatinine.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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