Drug interactions
Hydrochlorothiazide-irbesartan + L-methylfolate
Severity: Minor
Hydrochlorothiazide-irbesartan and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides have been associated with lower folate levels, possibly through increased renal loss. Any clinical effect is expected to be small in patients with adequate intake.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Proposed increased renal excretion of folate; mechanism is not firmly established.
What to do
No routine action is needed. Consider checking folate status in patients with deficiency risk or unexplained anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of L-methylfolate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with L-methylfolate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides have been associated with lower folate levels, possibly through increased renal loss. Any clinical effect is expected to be small in patients with adequate intake.
How serious is the interaction between Hydrochlorothiazide-irbesartan and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Consider checking folate status in patients with deficiency risk or unexplained anemia.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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