Drug interactions
Hydrochlorothiazide-irbesartan + Methoxsalen
Severity: Moderate
Hydrochlorothiazide-irbesartan and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a known photosensitizing drug, and methoxsalen is a potent photosensitizer used with UVA exposure. Combined use may increase the risk of phototoxic skin reactions such as severe sunburn.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive phototoxic effects of two photosensitizing agents.
What to do
Counsel on strict photoprotection and monitor skin for phototoxic reactions, adjusting UVA dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Methoxsalen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a known photosensitizing drug, and methoxsalen is a potent photosensitizer used with UVA exposure. Combined use may increase the risk of phototoxic skin reactions such as severe sunburn.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict photoprotection and monitor skin for phototoxic reactions, adjusting UVA dose if needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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