Drug interactions
Hydrochlorothiazide-irbesartan + Nebivolol
Severity: Minor
Hydrochlorothiazide-irbesartan and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol adds to the blood pressure lowering of irbesartan and hydrochlorothiazide. This is often intended but can cause hypotension, dizziness and bradycardia. Clinically relevant effects on potassium are small.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects via beta-1 blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or titrating. Check electrolytes and renal function at routine intervals.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Nebivolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nebivolol adds to the blood pressure lowering of irbesartan and hydrochlorothiazide. This is often intended but can cause hypotension, dizziness and bradycardia. Clinically relevant effects on potassium are small.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating. Check electrolytes and renal function at routine intervals.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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