Drug interactions
Hydrochlorothiazide-irbesartan + Paclitaxel
Severity: Minor
Hydrochlorothiazide-irbesartan and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan is a weak CYP2C8 substrate and inhibitor in vitro, but no clinically meaningful rise in paclitaxel exposure has been established. The interaction is largely theoretical.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Possible weak inhibition of CYP2C8-mediated paclitaxel metabolism, not shown to be clinically significant.
What to do
No dose change is needed; monitor for paclitaxel toxicity such as neuropathy and neutropenia as part of routine chemotherapy care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Paclitaxel?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irbesartan is a weak CYP2C8 substrate and inhibitor in vitro, but no clinically meaningful rise in paclitaxel exposure has been established. The interaction is largely theoretical.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for paclitaxel toxicity such as neuropathy and neutropenia as part of routine chemotherapy care.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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