Drug interactions
Hydrochlorothiazide-irbesartan + Piperacillin
Severity: Minor
Hydrochlorothiazide-irbesartan and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may modestly slow tubular secretion of piperacillin, but there is no well-documented clinical consequence. Hypokalemia can occur with piperacillin and thiazides together.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Piperacillin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; additive potassium loss.
What to do
No dose change is usually needed. Monitor serum potassium during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Piperacillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may modestly slow tubular secretion of piperacillin, but there is no well-documented clinical consequence. Hypokalemia can occur with piperacillin and thiazides together.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor serum potassium during therapy.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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