Drug interactions
Hydrochlorothiazide-irbesartan + Pivmecillinam
Severity: Minor
Hydrochlorothiazide-irbesartan and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly reduce renal tubular secretion of mecillinam, the active metabolite, raising its levels. The effect is small and rarely clinically significant.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Competition for renal tubular secretion of beta-lactams.
What to do
No dose adjustment is usually needed; monitor for beta-lactam adverse effects if renal function is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Pivmecillinam?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly reduce renal tubular secretion of mecillinam, the active metabolite, raising its levels. The effect is small and rarely clinically significant.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for beta-lactam adverse effects if renal function is reduced.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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