Drug interactions
Hydrochlorothiazide-irbesartan + Potassium citrate
Severity: Moderate
Hydrochlorothiazide-irbesartan and Potassium citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan reduces aldosterone-mediated potassium excretion, so potassium citrate supplementation can cause hyperkalemia, especially in renal impairment or diabetes. Hydrochlorothiazide tends to lower potassium and partly offsets this, but the net effect is unpredictable.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Potassium citrate belongs to Gastrointestinal Tract.
Why it happens
ARB-induced decrease in aldosterone-driven renal potassium excretion combined with an exogenous potassium load.
What to do
Check serum potassium and creatinine within the first week or two and periodically afterward. Reduce or stop the potassium supplement if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Potassium citrate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Potassium citrate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan reduces aldosterone-mediated potassium excretion, so potassium citrate supplementation can cause hyperkalemia, especially in renal impairment or diabetes. Hydrochlorothiazide tends to lower potassium and partly offsets this, but the net effect is unpredictable.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Potassium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine within the first week or two and periodically afterward. Reduce or stop the potassium supplement if potassium rises.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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