Drug interactions
Hydrochlorothiazide-irbesartan + Probenecid
Severity: Moderate
Hydrochlorothiazide-irbesartan and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise serum uric acid and may counteract the uricosuric effect of probenecid. Competition for renal tubular secretion may also change the levels of both drugs, so gout control may be reduced.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-induced urate retention and competition for organic anion transporters in the proximal tubule oppose probenecid's uricosuric action.
What to do
Monitor serum uric acid and gout symptoms, and increase the probenecid dose if needed. Consider a non-thiazide antihypertensive if gout control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Probenecid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise serum uric acid and may counteract the uricosuric effect of probenecid. Competition for renal tubular secretion may also change the levels of both drugs, so gout control may be reduced.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms, and increase the probenecid dose if needed. Consider a non-thiazide antihypertensive if gout control is poor.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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