Drug interactions
Hydrochlorothiazide-irbesartan + Tolazamide
Severity: Minor
Hydrochlorothiazide-irbesartan and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of sulfonylureas such as tolazamide. Loss of glycemic control may emerge after the thiazide is started or its dose increased.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Thiazides reduce insulin release and tissue insulin sensitivity, partly through potassium depletion, which opposes sulfonylurea action.
What to do
Monitor blood glucose after starting or changing the thiazide dose. Increase the antidiabetic dose if needed and correct hypokalemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Tolazamide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of sulfonylureas such as tolazamide. Loss of glycemic control may emerge after the thiazide is started or its dose increased.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the thiazide dose. Increase the antidiabetic dose if needed and correct hypokalemia.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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