Drug interactions
Hydrochlorothiazide-irbesartan + Tolbutamide
Severity: Minor
Hydrochlorothiazide-irbesartan and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and blunt the effect of tolbutamide. Glycemic control may worsen, particularly with higher thiazide doses.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Thiazides reduce insulin secretion and insulin sensitivity, partly via hypokalemia, opposing the sulfonylurea effect.
What to do
Monitor blood glucose when the thiazide is started or its dose changed. Adjust the tolbutamide dose if control deteriorates and keep potassium normal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Tolbutamide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and blunt the effect of tolbutamide. Glycemic control may worsen, particularly with higher thiazide doses.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the thiazide is started or its dose changed. Adjust the tolbutamide dose if control deteriorates and keep potassium normal.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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