Drug interactions
Hydrochlorothiazide-irbesartan + Verapamil
Severity: Minor
Hydrochlorothiazide-irbesartan and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A renal tubular competition effect on verapamil is theoretical and of little clinical importance because verapamil is cleared mainly by hepatic metabolism. Additive blood pressure lowering may occur, but this is generally expected and manageable.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Theoretical competition for renal tubular secretion; additive antihypertensive effects.
What to do
Monitor blood pressure and heart rate when combining; no dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Verapamil?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A renal tubular competition effect on verapamil is theoretical and of little clinical importance because verapamil is cleared mainly by hepatic metabolism. Additive blood pressure lowering may occur, but this is generally expected and manageable.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining; no dose change is usually needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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