Drug interactions
Hydrochlorothiazide-lisinopril + Labetalol
Severity: Minor
Hydrochlorothiazide-lisinopril and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds to the blood pressure lowering effect of the thiazide and ACE inhibitor, which can cause hypotension or orthostatic symptoms. Thiazides and beta blockers may also worsen glucose control, but no significant potassium problem is expected.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure and watch for orthostatic symptoms when starting or titrating, and adjust doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Labetalol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol adds to the blood pressure lowering effect of the thiazide and ACE inhibitor, which can cause hypotension or orthostatic symptoms. Thiazides and beta blockers may also worsen glucose control, but no significant potassium problem is expected.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for orthostatic symptoms when starting or titrating, and adjust doses as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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