Drug interactions
Hydrochlorothiazide-lisinopril + Liraglutide
Severity: Minor
Hydrochlorothiazide-lisinopril and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can worsen glucose tolerance and may partly offset the glucose lowering effect of liraglutide. Gastrointestinal fluid loss from liraglutide combined with the diuretic and ACE inhibitor can also contribute to volume depletion and kidney injury.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Thiazides reduce insulin sensitivity and secretion, opposing GLP-1 agonist effects, and liraglutide-related fluid loss may add to diuretic volume depletion.
What to do
Monitor glycemic control when starting or changing the thiazide dose, and ensure adequate hydration with renal function monitoring if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Liraglutide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides can worsen glucose tolerance and may partly offset the glucose lowering effect of liraglutide. Gastrointestinal fluid loss from liraglutide combined with the diuretic and ACE inhibitor can also contribute to volume depletion and kidney injury.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or changing the thiazide dose, and ensure adequate hydration with renal function monitoring if vomiting or diarrhea occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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