Drug interactions
Hydrochlorothiazide-lisinopril + Lornoxicam
Severity: Moderate
Hydrochlorothiazide-lisinopril and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of ACE inhibitors and thiazides and, together with them, raise the risk of acute kidney injury, especially with volume depletion or in older patients. NSAIDs can also contribute to hyperkalemia with the ACE inhibitor.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reduced glomerular perfusion, which counteracts the antihypertensive effect and impairs renal function when combined with ACE inhibition and diuresis.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the NSAID and periodically thereafter. Keep the patient hydrated and use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Lornoxicam?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of ACE inhibitors and thiazides and, together with them, raise the risk of acute kidney injury, especially with volume depletion or in older patients. NSAIDs can also contribute to hyperkalemia with the ACE inhibitor.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the NSAID and periodically thereafter. Keep the patient hydrated and use the lowest NSAID dose for the shortest time.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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