Drug interactions
Hydrochlorothiazide-lisinopril + Losartan
Severity: Major
Hydrochlorothiazide-lisinopril and Losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade, which increases the risk of hypotension, hyperkalemia, and renal impairment without clear added benefit. The thiazide partly offsets potassium retention but does not remove the risk.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive blockade of the renin-angiotensin-aldosterone system reduces aldosterone-mediated potassium excretion and efferent arteriolar tone.
What to do
Avoid routine dual ACE inhibitor and ARB therapy, particularly in diabetic nephropathy. If unavoidable, monitor potassium, creatinine, and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Losartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade, which increases the risk of hypotension, hyperkalemia, and renal impairment without clear added benefit. The thiazide partly offsets potassium retention but does not remove the risk.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine dual ACE inhibitor and ARB therapy, particularly in diabetic nephropathy. If unavoidable, monitor potassium, creatinine, and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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