Drug interactions
Hydrochlorothiazide-lisinopril + Mefenamic acid
Severity: Moderate
Hydrochlorothiazide-lisinopril and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid can reduce the blood pressure lowering effect of the ACE inhibitor and thiazide and raise the risk of acute kidney injury and hyperkalemia, especially with dehydration or existing renal disease.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced glomerular perfusion, which opposes the antihypertensive and diuretic effects.
What to do
Monitor blood pressure, serum creatinine, and potassium, and keep the NSAID course short. Consider paracetamol as an alternative where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Mefenamic acid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid can reduce the blood pressure lowering effect of the ACE inhibitor and thiazide and raise the risk of acute kidney injury and hyperkalemia, especially with dehydration or existing renal disease.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine, and potassium, and keep the NSAID course short. Consider paracetamol as an alternative where appropriate.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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