Drug interactions
Hydrochlorothiazide-lisinopril + Memantine
Severity: Minor
Hydrochlorothiazide-lisinopril and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated mainly by the kidney with some tubular secretion. Thiazides could modestly compete for this pathway, but a clinically meaningful rise in memantine exposure has not been established.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular cationic secretion; the clinical relevance is unproven.
What to do
No dose change is usually needed; watch for dizziness, confusion or other memantine adverse effects, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Memantine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated mainly by the kidney with some tubular secretion. Thiazides could modestly compete for this pathway, but a clinically meaningful rise in memantine exposure has not been established.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for dizziness, confusion or other memantine adverse effects, particularly in renal impairment.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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