Drug interactions
Hydrochlorothiazide-lisinopril + Metoprolol
Severity: Minor
Hydrochlorothiazide-lisinopril and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with an ACE inhibitor and thiazide gives additive blood pressure lowering, which is often intended but may cause hypotension or bradycardia. Thiazides can also modestly worsen glucose and lipid parameters, which beta-blockers may compound.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure and heart rate when starting or adjusting therapy. Check glucose in patients with diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Metoprolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a beta-blocker with an ACE inhibitor and thiazide gives additive blood pressure lowering, which is often intended but may cause hypotension or bradycardia. Thiazides can also modestly worsen glucose and lipid parameters, which beta-blockers may compound.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting therapy. Check glucose in patients with diabetes.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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