Drug interactions
Hydrochlorothiazide-lisinopril + Nabumetone
Severity: Moderate
Hydrochlorothiazide-lisinopril and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone may reduce the antihypertensive effect of the ACE inhibitor and thiazide and increase the risk of kidney injury and hyperkalemia, particularly with dehydration or pre-existing renal disease.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced glomerular perfusion, which opposes the antihypertensive and diuretic effects.
What to do
Monitor blood pressure, serum creatinine, and potassium during co-therapy and keep NSAID duration short. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Nabumetone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone may reduce the antihypertensive effect of the ACE inhibitor and thiazide and increase the risk of kidney injury and hyperkalemia, particularly with dehydration or pre-existing renal disease.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine, and potassium during co-therapy and keep NSAID duration short. Ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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