Drug interactions
Hydrochlorothiazide-lisinopril + Succinylcholine
Severity: Moderate
Hydrochlorothiazide-lisinopril and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can transiently raise serum potassium, while thiazide-induced electrolyte disturbances may alter neuromuscular blockade and arrhythmia risk. With an ACE inhibitor present, potassium shifts may be less predictable.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Depolarizing blockade releases intracellular potassium, and diuretic-related electrolyte abnormalities modify neuromuscular and cardiac responses.
What to do
Check serum potassium and magnesium before surgery and correct abnormalities. Monitor the ECG and neuromuscular function during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Succinylcholine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can transiently raise serum potassium, while thiazide-induced electrolyte disturbances may alter neuromuscular blockade and arrhythmia risk. With an ACE inhibitor present, potassium shifts may be less predictable.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before surgery and correct abnormalities. Monitor the ECG and neuromuscular function during anesthesia.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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