Drug interactions
Hydrochlorothiazide-lisinopril + Torsemide
Severity: Moderate
Hydrochlorothiazide-lisinopril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide and hydrochlorothiazide both promote urinary potassium and magnesium loss, and sequential nephron blockade can produce a strong diuresis. This can cause hypokalemia, hyponatremia, volume depletion and hypotension, with a risk of arrhythmias. Lisinopril may lessen potassium loss but increases the risk of first-dose hypotension and renal impairment when volume depleted.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Additive natriuresis and kaliuresis from loop and thiazide diuretic action at sequential nephron sites.
What to do
Monitor electrolytes, renal function, weight and blood pressure, and consider lowering diuretic doses if volume depletion appears. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Torsemide
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Torsemide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Torsemide and hydrochlorothiazide both promote urinary potassium and magnesium loss, and sequential nephron blockade can produce a strong diuresis. This can cause hypokalemia, hyponatremia, volume depletion and hypotension, with a risk of arrhythmias. Lisinopril may lessen potassium loss but increases the risk of first-dose hypotension and renal impairment when volume depleted.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, and consider lowering diuretic doses if volume depletion appears. Replace potassium and magnesium as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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