Drug interactions
Hydrochlorothiazide-losartan + Idelalisib
Severity: Minor
Hydrochlorothiazide-losartan and Idelalisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can reduce conversion of losartan to its active carboxylic acid metabolite. This may slightly lessen the antihypertensive effect, though losartan itself is active and the clinical effect is modest.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Idelalisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition by idelalisib reducing the formation of the active metabolite of losartan.
What to do
Monitor blood pressure and adjust the antihypertensive regimen if control worsens; no empirical dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Idelalisib?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Idelalisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A inhibitor and can reduce conversion of losartan to its active carboxylic acid metabolite. This may slightly lessen the antihypertensive effect, though losartan itself is active and the clinical effect is modest.
How serious is the interaction between Hydrochlorothiazide-losartan and Idelalisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the antihypertensive regimen if control worsens; no empirical dose change is required.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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