Drug interactions
Hydrochlorothiazide-losartan + Levoketoconazole
Severity: Moderate
Hydrochlorothiazide-losartan and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP2C9 and CYP3A4, which convert losartan to its active metabolite E-3174. This may alter losartan's effect, usually reducing active metabolite formation, though the clinical relevance is uncertain.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 and CYP3A4 reduces the conversion of losartan to E-3174.
What to do
Monitor blood pressure response and adjust the losartan dose if control changes after levoketoconazole is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Levoketoconazole?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP2C9 and CYP3A4, which convert losartan to its active metabolite E-3174. This may alter losartan's effect, usually reducing active metabolite formation, though the clinical relevance is uncertain.
How serious is the interaction between Hydrochlorothiazide-losartan and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure response and adjust the losartan dose if control changes after levoketoconazole is started or stopped.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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