Drug interactions
Hydrochlorothiazide-losartan + Methylprednisolone
Severity: Minor
Hydrochlorothiazide-losartan and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and corticosteroids promote urinary potassium loss, so together they can cause hypokalemia. Methylprednisolone has little mineralocorticoid activity, so the risk is lower than with hydrocortisone but still present with high doses.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting.
What to do
Monitor serum potassium during prolonged or high-dose steroid therapy and replace as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Methylprednisolone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both hydrochlorothiazide and corticosteroids promote urinary potassium loss, so together they can cause hypokalemia. Methylprednisolone has little mineralocorticoid activity, so the risk is lower than with hydrocortisone but still present with high doses.
How serious is the interaction between Hydrochlorothiazide-losartan and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during prolonged or high-dose steroid therapy and replace as needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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