Drug interactions
Hydrochlorothiazide-losartan + Stiripentol
Severity: Minor
Hydrochlorothiazide-losartan and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes including CYP2C19, CYP3A4 and CYP1A2. Losartan activation relies on CYP2C9 and CYP3A4, so effects on blood pressure control may be unpredictable but are probably modest.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity, possibly altering losartan conversion to its active metabolite.
What to do
Monitor blood pressure when stiripentol is started, stopped or changed. Adjust losartan dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Stiripentol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits and induces several CYP enzymes including CYP2C19, CYP3A4 and CYP1A2. Losartan activation relies on CYP2C9 and CYP3A4, so effects on blood pressure control may be unpredictable but are probably modest.
How serious is the interaction between Hydrochlorothiazide-losartan and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when stiripentol is started, stopped or changed. Adjust losartan dose if control changes.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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