Drug interactions
Hydrochlorothiazide-telmisartan + Momelotinib
Severity: Moderate
Hydrochlorothiazide-telmisartan and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib is an OATP1B1/3 substrate and telmisartan may inhibit these transporters, potentially raising momelotinib exposure. This may increase momelotinib adverse effects, though the magnitude is uncertain.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Momelotinib belongs to Oncology.
Why it happens
Inhibition of OATP1B1/3-mediated hepatic uptake of momelotinib by telmisartan.
What to do
Monitor for momelotinib adverse effects such as thrombocytopenia, GI effects and hypotension. Consider an alternative antihypertensive if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Momelotinib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib is an OATP1B1/3 substrate and telmisartan may inhibit these transporters, potentially raising momelotinib exposure. This may increase momelotinib adverse effects, though the magnitude is uncertain.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for momelotinib adverse effects such as thrombocytopenia, GI effects and hypotension. Consider an alternative antihypertensive if toxicity emerges.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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