Drug interactions
Hydrochlorothiazide-telmisartan + Toremifene
Severity: Moderate
Hydrochlorothiazide-telmisartan and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can cause hypercalcemia, particularly in patients with bone metastases, and thiazide diuretics reduce urinary calcium excretion. Using both can increase the risk of clinically significant hypercalcemia.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide-mediated reduction in renal calcium excretion adds to toremifene-associated hypercalcemia.
What to do
Monitor serum calcium regularly, especially early in therapy, and consider switching the thiazide to another antihypertensive class if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Toremifene?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can cause hypercalcemia, particularly in patients with bone metastases, and thiazide diuretics reduce urinary calcium excretion. Using both can increase the risk of clinically significant hypercalcemia.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium regularly, especially early in therapy, and consider switching the thiazide to another antihypertensive class if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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