Drug interactions
Hydrochlorothiazide-valsartan + Verteporfin
Severity: Minor
Hydrochlorothiazide-valsartan and Verteporfin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing and may add to the phototoxic potential of verteporfin after photodynamic therapy. The risk is mainly skin photosensitivity reactions in the days after treatment.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Verteporfin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Verteporfin belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects.
What to do
Counsel the patient to avoid direct sunlight and bright indoor light on exposed skin for the period advised in the verteporfin labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Verteporfin
- Doxycycline + Verteporfin Moderate
- Griseofulvin + Verteporfin Moderate
- Minocycline + Verteporfin Moderate
- Tetracycline + Verteporfin Moderate
- Adapalene + Verteporfin Minor
- Amlodipine-hydrochlorothiazide-valsartan + Verteporfin Minor
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Verteporfin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Verteporfin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is photosensitizing and may add to the phototoxic potential of verteporfin after photodynamic therapy. The risk is mainly skin photosensitivity reactions in the days after treatment.
How serious is the interaction between Hydrochlorothiazide-valsartan and Verteporfin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid direct sunlight and bright indoor light on exposed skin for the period advised in the verteporfin labeling.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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